This study investigates the effects of a test drug on angiogenesis following ischemic stroke in rats. The drug is administered after inducing a stroke through middle cerebral artery occlusion, and its impact on brain tissue recovery is assessed using MRI scans.
Begin with a rat subjected to middle cerebral artery occlusion, a surgical procedure that temporarily blocks blood flow to the brain tissue.
This induces an ischemic stroke, leading to brain tissue damage.
Next, remove the blockage to restore blood flow.
Select rats that exhibit neurological deficits to ensure study relevance.
Then, administer the test drug to the experimental group while injecting saline into the other group.
Repeat the drug and saline administration.
The test drug promotes angiogenesis, resulting in the formation of new blood vessels.
This enhances blood supply to the damaged brain tissue and reduces the stroke effects.
Next, anesthetize the rat and use a heating blanket to maintain body temperature.
After a few days, perform MRI scans for both groups.
In the MRI images, a brighter region in the saline-injected group indicates the stroke-affected area.
Meanwhile, the reduced brightness in the experimental group suggests drug-induced angiogenesis.
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