Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation

作者：Pamela K. Douglas1,2, Maureen Pisani2, Rory Reid1, Austin Head2, Edward Lau2, Ebrahim Mirakhor3, Jennifer Bramen2, Billi Gordon2, Ariana Anderson2, Wesley T. Kerr2, Chajoon Cheong4, Mark S. Cohen1,2 1Neuropsychiatric Institute,University of California, Los Angeles, 2Laboratory of Neuroimaging Technology,University of California, Los Angeles, 3Yale School of Medicine, 4Korean Basic Science Institute

简介：We present a protocol for concurrent collection of EEG/fMRI data, and synchronized MR clock signal recording. We demonstrate this method using a unique paradigm whereby subjects receive ‘cold glove’ instructions during scanning, and EEG/fMRI data are recorded along with hand temperature measurements both before and after hypnotic induction.

Overview

This article presents a novel protocol for the concurrent collection of EEG and fMRI data, along with synchronized MR clock signal recording. The method is demonstrated through a unique paradigm known as the cold glove experiment, where subjects experience temperature changes in their hands during hypnotic induction.

Key Study Components

Area of Science

Neuroscience
Electrophysiology
Functional Imaging

Background

Simultaneous EEG and fMRI data collection is challenging due to device artifacts.
Hypnosis can alter physiological responses, making it a valuable experimental paradigm.
Differential thermometry can provide insights into cognitive processes.
Existing methods typically isolate EEG or fMRI, limiting multimodal data analysis.

Purpose of Study

To develop a method for simultaneous EEG and fMRI data collection.
To explore the effects of hypnotic induction on hand temperature perception.
To enhance the understanding of cognitive processes through multimodal data.

Methods Used

Concurrent EEG and fMRI data collection using specialized equipment.
Implementation of a cold glove paradigm during hypnotic induction.
Use of MR-compatible differential thermometry for temperature measurement.
Calibration of temperature sensors to ensure accurate readings.

Main Results

Successful collection of multimodal data revealing brain and physiological responses.
Demonstrated the feasibility of simultaneous EEG and fMRI recordings.
Quantified the effects of hypnotic suggestions on hand temperature.
Showed that the method can expose linkages between cognitive processes and physiological changes.

Conclusions

The developed method allows for high-resolution, non-invasive data collection.
Simultaneous recordings provide advantages over traditional serial data collection.
This approach can be applied to various experimental paradigms in neuroscience.

Frequently Asked Questions

What is the cold glove experiment?

The cold glove experiment involves instructing subjects to imagine their hand becoming colder, while measuring physiological responses during EEG and fMRI scans.

How does hypnosis affect physiological measurements?

Hypnosis can alter sensations and perceptions, which can be quantitatively measured through changes in hand temperature during the experiment.

What challenges are associated with simultaneous EEG and fMRI?

The main challenges include artifacts created by each device that can interfere with the accuracy of the recordings.

What technology is used for differential thermometry?

MR-compatible temperature sensors are used to measure hand temperature changes during the experiment.

Why is multimodal data collection important?

It provides a more comprehensive understanding of the relationship between brain activity and physiological responses, enhancing research in cognitive neuroscience.

How are the EEG and fMRI systems synchronized?

The timing of both instruments is aligned with nanosecond precision to ensure accurate data collection.