A Microfluidic Chip for ICPMS Sample Introduction

Overview

This article presents a discrete droplet sample introduction system for inductively coupled plasma mass spectrometry (ICPMS). The system utilizes a cost-effective microfluidic chip to generate highly monodisperse droplets in the size range of 40−60 µm at frequencies from 90 to 7,000 Hz.

Key Study Components

Area of Science

• Mass spectrometry
• Microfluidics
• Analytical chemistry

Background

• Inductively coupled plasma mass spectrometry (ICPMS) is a powerful analytical technique.
• Microfluidic systems enable precise control over fluid dynamics.
• Monodisperse droplets are essential for consistent sample analysis.
• PDMS is commonly used in microfluidic chip fabrication.

Purpose of Study

• To generate and analyze the elemental composition of monodispersed micro droplets.
• To facilitate the analysis of single cells or aqueous solutions.
• To improve the efficiency of sample introduction in ICPMS.

Methods Used

• Fabrication of a microfluidic chip using replica molding with PDMS.
• Connection of syringe pumps to supply aqueous samples and organic carrier phases.
• Generation of monodisperse droplets through flow focusing.
• Evaporation of droplets and removal of solvents prior to ionization and detection.

Main Results

• Successful generation of monodisperse droplets in the desired size range.
• Efficient sample introduction into the ICPMS system.
• Quantitative analysis of elemental composition achieved.
• Demonstration of the system's effectiveness for single cell analysis.

Conclusions

• The developed system enhances the capabilities of ICPMS.
• Microfluidic technology provides a viable solution for droplet generation.
• Potential applications in various fields of analytical chemistry.

Frequently Asked Questions