A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

作者： Venkatesh Mani1, Nadia Alie1, Sarayu Ramachandran1, Philip M. Robson1, Cecilia Besa1, Gregory Piazza2, Michele Mercuri3, Michael Grosso3, Bachir Taouli1, Samuel Z. Goldhaber2, Zahi A. Fayad1 1Department of Radiology, Translational and Molecular Imaging Institute,Icahn School of Medicine at Mount Sinai, 2Cardiovascular Division,Brigham and Women's Hospital, Harvard Medical School, 3Daiichi Sankyo Pharma Development

简介：

Overview

This study aims to evaluate deep vein thrombosis (DVT) using magnetic resonance imaging (MRI) in a multicenter clinical trial. The research focuses on two imaging methods to quantify thrombus volume effectively.

Key Study Components

Area of Science

• Neuroscience
• Medical Imaging
• Clinical Trials

Background

• Deep vein thrombosis (DVT) is a significant medical condition.
• Accurate imaging techniques are essential for diagnosis and treatment.
• Magnetic resonance venography offers a non-invasive imaging option.
• Long-circulating gadolinium-based contrast agents enhance imaging quality.

Purpose of Study

• To quantitatively evaluate DVT volume using MRI.
• To assess inter- and intra-observer variability in imaging results.
• To establish the reproducibility of the imaging protocol.

Methods Used

• Insertion of an intravenous line into the subject.
• Positioning the subject in the MRI scanner.
• Direct thrombus imaging using a three DT one weighted gradient ECHO scan.
• Magnetic resonance venography after injecting a long-circulating contrast agent.

Main Results

• Quantification of total thrombus volume was achieved.
• Inter- and intra-observer variability assessments were conducted.
• The protocol demonstrated reproducibility across different centers.

Conclusions

• The study successfully utilized MRI for DVT evaluation.
• Findings support the reliability of the imaging methods used.
• Results may enhance clinical practices in diagnosing DVT.

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