Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

作者： Eleonora M. de Leede1, Mark C. Burgmans2, Christian H. Martini3, Fred G. J. Tijl4, Arian R. van Erkel2, Jaap Vuyk3, Ellen Kapiteijn5, Cornelis Verhoef6, Cornelis J. H. van de Velde1, Alexander L. Vahrmeijer1 1Department of Surgery,Leiden University Medical Centre, 2Department of Radiology,Leiden University Medical Centre, 3Department of Anesthesiology,Leiden University Medical Centre, 4Department of Extracorporeal Circulation,Leiden University Medical Centre, 5Department of Medical Oncology,Leiden University Medical Centre, 6Department of Surgery,Erasmus MC Cancer Institute

简介：

Overview

This manuscript describes percutaneous isolated hepatic perfusion with simultaneous chemofiltration as a treatment for unresectable liver metastases. The procedure is minimally invasive and performed under general anesthesia by a skilled team.

Key Study Components

Area of Science

• Interventional Radiology
• Oncology
• Minimally Invasive Surgery

Background

• Unresectable liver metastases pose significant treatment challenges.
• High-dose chemotherapy can be delivered directly to the liver.
• Minimally invasive techniques reduce recovery time.
• Simultaneous chemofiltration minimizes systemic exposure to chemotherapy.

Purpose of Study

• To evaluate the efficacy of percutaneous hepatic perfusion.
• To assess the safety and repeatability of the procedure.
• To demonstrate the procedure's advantages over traditional methods.

Methods Used

• Pre-procedural angiography performed days prior to the PHP.
• General anesthesia administered by an anesthesiologist.
• Collaboration between interventional radiologist and clinical perfusionist.
• Use of chemofiltration during the perfusion process.

Main Results

• High doses of chemotherapy delivered effectively to the liver.
• Low morbidity and mortality rates associated with the procedure.
• Procedure can be repeated for ongoing treatment.
• Demonstrated successful outcomes in patient cases.

Conclusions

• Percutaneous hepatic perfusion is a viable treatment for liver metastases.
• Minimally invasive nature enhances patient recovery.
• Further studies may expand its application in oncology.

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