A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

作者： Matthew S. Sherwood1,2, Emily E. Diller2, Elizabeth Ey3, Subhashini Ganapathy2,4, Jeremy T. Nelson5, Jason G. Parker1,6 1Office of the Vice President for Research and Graduate Studies,Wright State University, 2Department of Biomedical, Industrial and Human Factors Engineering,Wright State University, 3Pediatric Radiology and Medical Imaging,Dayton Children's Hospital, 4Department of Trauma Care and Surgery, Boonshoft School of Medicine,Wright State University, 5Department of Defense Hearing Center of Excellence,JBSA-Lackland, 6Department of Neurology, Boonshoft School of Medicine,Wright State University

简介：

Overview

This article presents a protocol for using neurofeedback training with functional magnetic resonance imaging (fMRI) to modulate brain function. The ability to control neural plasticity is crucial for treating neurologic disorders and aiding recovery from brain injuries.

Key Study Components

Area of Science

• Neuroscience
• Neurofeedback
• Functional Magnetic Resonance Imaging

Background

• Neurofeedback training can alter synaptic potentials in targeted brain regions.
• This technique offers a non-invasive alternative to pharmaceuticals and surgery.
• It is particularly relevant for conditions like autism, traumatic brain injury, and tinnitus.
• Real-time feedback based on brain activity can enhance training effectiveness.

Purpose of Study

• To enable localized control over neuroplastic mechanisms in the human brain.
• To provide a systematic approach for subjects to alter their brain activity.
• To develop a method that can be implemented on accessible platforms like smartphones.

Methods Used

• Participants undergo fMRI while receiving neurofeedback.
• Real-time data acquisition is synchronized with auditory stimuli.
• Activation maps are generated to identify target brain regions.
• Participants are instructed to perform mindfulness tasks to influence brain activity.

Main Results

• Significant control over the left DLPFC was achieved across multiple sessions.
• Neurofeedback combined with mindfulness practice resulted in focal brain activity changes.
• Training sessions can be completed in as little as 20 minutes.

Conclusions

• Neurofeedback training is a promising tool for enhancing brain function.
• Careful selection of target brain regions is crucial for effective training.
• Additional imaging methods can provide further insights into neuroplastic changes.

Frequently Asked Questions