Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release

作者： Chih-Yu Kuo1, Ting-Yu Liu2, Kuan-Syun Wang2, Andri Hardiansyah3, Yen-Ting Lin4, Hsueh-Yung Chen4, Wen-Yen Chiu1,4,5 1Institute of Polymer Science and Engineering,National Taiwan University, 2Department of Materials Engineering,Ming Chi University of Technology, 3Department of Metallurgy and Materials Engineering,Bandung Institute of Technology and Science, 4Department of Chemical Engineering,National Taiwan University, 5Department of Materials Science and Engineering,National Taiwan University

简介：

Overview

This manuscript describes the preparation of magnetic and thermal-sensitive microgels via a temperature-induced emulsion without chemical reaction. These microgels are synthesized for potential use in magnetically and thermally triggered drug-release applications.

Key Study Components

Area of Science

• Neuroscience
• Biotechnology
• Drug Delivery Systems

Background

• Hydrophobic anti-cancer drugs like curcumin require effective encapsulation for targeted delivery.
• Magnetic and thermal-sensitive hydrogels can enhance localized drug delivery to tumor cells.
• Poly(N-isopropylacrylamide) (PNIPAAm) is a key component in the synthesis of these microgels.
• Magnetic nanoparticles facilitate the targeted release of drugs using external magnetic fields.

Purpose of Study

• To investigate the behaviors of curcumin-loaded hydrogels during magnetically triggered release.
• To explore the encapsulation of hydrophobic drugs for localized delivery.
• To provide insights into thermal-induced self-assemblies of PNIPAAm.

Methods Used

• Preparation of microgels using poly(N-isopropylacrylamide), polyethylenimine, and iron oxide nanoparticles.
• Temperature-induced emulsion technique without chemical reactions.
• Combination of different concentrations of PEI and PNIPAAm with iron oxide nanoparticles.
• Investigation of curcumin release dynamics under magnetic fields.

Main Results

• Successful synthesis of magnetic and thermal-sensitive microgels.
• Demonstrated effective encapsulation of curcumin for targeted drug delivery.
• Revealed insights into the release mechanisms of hydrophobic drugs.
• Highlighted the potential applications of this method in drug delivery systems.

Conclusions

• The developed microgels show promise for targeted anti-cancer drug delivery.
• This method can be adapted for other substances and applications.
• Further research is needed to optimize the release profiles of encapsulated drugs.

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