Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

作者： Canzhen Ma*1,2, Shuwei Shen*1,2, Guangli Liu1, Siyue Guo1,2, Buyun Guo1,2, Jialuo Li1,2, Kuiming Huang1,2, Yidan Zheng1, Pengfei Shao1,2, Erbao Dong1,2, Jiaru Chu1, Ronald X. Xu1,2,3 1Department of Precision Machinery and Precision Instrumentation,University of Science and Technology of China, 2Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes,University of Science and Technology of China, 3Department of Biomedical Engineering,The Ohio State University

简介：

Overview

This article discusses the integration of spin coating, polyjet printing, and fused deposition modeling to create multilayered heterogeneous phantoms. These phantoms are designed to simulate the structural and functional properties of biological tissue.

Key Study Components

Area of Science

• Biomedical Engineering
• 3D Printing Technology
• Biomaterials

Background

• There is a lack of traceable phantom standards for simulating biological tissue.
• This gap hinders the development and validation of biomedical optical devices.
• Heterogeneous phantoms can improve the accuracy of these devices.
• Multiple additive manufacturing processes can be combined for effective fabrication.

Purpose of Study

• To demonstrate the layer-by-layer fabrication of tissue-simulating phantoms.
• To showcase the integration of various 3D printing techniques.
• To address the need for standards in biomedical optical device testing.

Methods Used

• Integration of spin coating, PolyJet printing, and FDM.
• Automatic printing of skin-simulating phantoms.
• Preparation of materials, including titanium dioxide in photopolymer resin.
• Layering to create structures that mimic epidermis, dermis, and tumors.

Main Results

• Successful fabrication of multilayered phantoms.
• Demonstrated technical capabilities of the production line.
• Phantoms accurately simulate the structural and functional properties of biological tissue.
• Potential applications in testing biomedical optical devices.

Conclusions

• The integration of multiple 3D printing techniques is effective for phantom fabrication.
• These phantoms can serve as valuable tools for biomedical research.
• Further development of standards is essential for advancing optical device validation.

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