In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

作者： Rachael S. Allen1,2, Katie Bales1,3, Andrew Feola1,2, Machelle T Pardue1,2,3 1Center of Excellence for Visual and Neurocognitive Rehabilitation,Atlanta Veterans Affairs Medical Center, 2Department of Biomedical Engineering,Georgia Institute of Technology, 3Department of Ophthalmology,Emory University

简介：

Overview

This article discusses the application of spectral-domain optical coherence tomography (SD-OCT) for in vivo imaging of retinal and ocular structures. It highlights the technique's utility in various eye disease models, including retinal degeneration and glaucoma.

Key Study Components

Area of Science

• Ophthalmology
• Neuroscience
• Imaging Techniques

Background

• SD-OCT is a non-invasive imaging method.
• It allows for real-time visualization of ocular structures.
• The technique is crucial for monitoring eye diseases.
• Different protocols may be needed for various research applications.

Purpose of Study

• To demonstrate the use of SD-OCT in eye disease models.
• To measure retinal thickness in diabetic retinopathy.
• To assess changes in glaucoma and myopia models.

Methods Used

• Utilization of spectral-domain optical coherence tomography.
• Measurement of retinal thickness and cupping.
• Tracking axial length in myopia models.
• Implementation of various imaging protocols.

Main Results

• Successful imaging of retinal structures in vivo.
• Effective tracking of ocular changes over time.
• Demonstrated the importance of protocol optimization.
• Provided insights into the progression of eye diseases.

Conclusions

• SD-OCT is a valuable tool for ocular research.
• It enhances understanding of retinal diseases.
• Further studies can refine imaging techniques.

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