Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

作者： Gábor B Brenner*1,2, Zoltán Giricz*1,2, Rita Garamvölgyi3,4, András Makkos1, Zsófia Onódi1, Nabil V Sayour1, Tamás G Gergely1, Tamás Baranyai1, Örs Petneházy3,4, Dénes Kőrösi3, Gergő P. Szabó3, Hajnalka Vago5, Zsófia Dohy5, Csilla Czimbalmos5, Béla Merkely5, Swetlana Boldin-Adamsky6, Elena Feinstein6, Iván G Horváth7, Péter Ferdinandy1,2 1Department of Pharmacology and Pharmacotherapy,Semmelweis University, 2Pharmahungary Group, 3Diagnostic, Radiation Oncology, Research and Teaching Center,Moritz Kaposi Somogy County Teaching Hospital, 4Faculty of Agricultural and Environmental Sciences,Kaposvar University, 5Heart and Vascular Center,Semmelweis University, 6Quark Pharmaceuticals, Inc, 7Heart Institute, Medical School,University of Pécs

简介：

Overview

This study presents techniques for inducing myocardial infarction (MI) and post-MI heart failure (HF) in closed-chest adult Göttingen minipigs. It also characterizes the post-MI HF model in minipigs compared to Landrace pigs.

Key Study Components

Area of Science

• Cardiovascular disease research
• Animal model development
• Myocardial infarction studies

Background

• Myocardial infarction leads to heart failure, necessitating effective animal models for research.
• Göttingen minipigs provide a larger model for studying chronic heart conditions compared to smaller animals.
• Previous cardioprotective therapies have failed in clinical trials, highlighting the need for better translational models.
• Landrace pigs have shorter assessment periods, limiting their utility in long-term studies.

Purpose of Study

• To establish a reliable model of post-MI HF in Göttingen minipigs.
• To assess myocardial function and morphology using cardiac magnetic resonance imaging.
• To evaluate chronic consequences of MI over extended periods.

Methods Used

• Induction of MI via intraluminal occlusion of the left anterior descending coronary artery.
• Baseline cardiac imaging performed prior to MI induction.
• Longitudinal assessment of cardiac function and morphology at various time points.
• Use of anesthesia and surgical techniques for intervention.

Main Results

• Successful induction of MI and subsequent heart failure in Göttingen minipigs.
• Characterization of myocardial function and morphology over time.
• Comparison of outcomes between Göttingen minipigs and Landrace pigs.
• Insights into the translational value of large animal models for cardioprotective therapy development.

Conclusions

• The Göttingen minipig model provides a valuable platform for studying post-MI HF.
• Longer assessment periods may improve the understanding of chronic heart failure mechanisms.
• Further development of cardioprotective therapies is essential for clinical success.

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