Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

作者： Datta Singh Goolaub1,2, Davide Marini3,4, Mike Seed4,5, Christopher K. Macgowan1,2 1Department of Medical Biophysics,University of Toronto, 2Division of Translational Medicine,The Hospital for Sick Children, 3Labatt Family Heart Centre,The Hospital for Sick Children, 4Department of Pediatrics,University of Toronto, 5Division of Pediatric Cardiology,The Hospital for Sick Children

简介：

Overview

This article presents a protocol for rapidly measuring fetal blood flow using MRI. It addresses challenges such as fetal motion and the need for high spatial and temporal resolution.

Key Study Components

Area of Science

• Neuroscience
• Medical Imaging
• Fetal Medicine

Background

• Fetal MRI is challenged by motion artifacts.
• High resolution is crucial for accurate imaging.
• External gating methods are often unavailable.
• Accelerated imaging techniques can improve outcomes.

Purpose of Study

• To develop a protocol for measuring fetal blood flow.
• To implement motion correction and cardiac gating retrospectively.
• To enhance monitoring of fetal pathologies.

Methods Used

• Use of compressed sensing for accelerated imaging.
• Localizer exam to locate the fetal body and vasculature.
• Specific imaging parameters for resolution and orientation.
• Retrospective correction for fetal motion during imaging.

Main Results

• Successful measurement of fetal blood flow with reduced imaging time.
• Effective motion correction achieved through the protocol.
• Extraction of fetal heart rate using optimized gating.
• Potential applications for monitoring congenital heart disease.

Conclusions

• The protocol shows promise for clinical applications in fetal monitoring.
• Further research is needed to validate the technique.
• Potential to guide therapy for fetal pathologies.

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