Personalized 3D-printed Headgear for Multi-electrode Transcranial Electrical Stimulation

作者： Benjamin M. Hampstead1,2, Annalise Rahman-Filipiak1, Kayla Rinna1, Stephen Schlaefflin1, Kenneth Petscavage1, Alexander R. Guillen3, Kamran Nazim3, Jeffrey Moreno3, Abhishek Datta3, Marom Bikson4, Alexandru D. Iordan1 1Research Program on Cognition and Neuromodulation Based Interventions, Departments of Psychiatry & Neurology,University of Michigan, Ann Arbor, 2Mental Health Service,VA Ann Arbor Healthcare System, 3Research and Development,Soterix Medical, 4Department of Biomedical Engineering,City College of New York

简介：

Overview

This study introduces a patented, personalized 3D-printed headgear designed for the rapid and reliable delivery of multi-electrode transcranial electrical stimulation (ME-tES). The headgear facilitates both in-office and remote applications, enhancing accessibility and precision in neuromodulation treatments.

Key Study Components

Area of Science

• Neuroscience
• Neuromodulation
• Cognitive and emotional health

Background

• The study aims to identify brain changes linked to cognitive and emotional deficits in dementia.
• It utilizes neuromodulation techniques as treatment targets for improving daily functioning.
• The headgear allows for easy setup and accurate electrode placement, even remotely.
• Participants undergo MRI scans to create individualized computational models for current flow.

Purpose of Study

• To develop a user-friendly headgear for effective ME-tES delivery.
• To train study partners in the setup and operation of the headgear.
• To validate the accuracy of electrode placements and improve participant outcomes.

Methods Used

• Acquisition of structural T1 MRI scans for brain segmentation.
• Creation of individualized computational models for electric current flow.
• 3D printing of headgear based on participant-specific models.
• Training study partners in headgear setup and device operation.

Main Results

• Electrode locations differed by an average of only 8.6 mm from hand-measured locations.
• Study partners achieved an average deviation of 1.74 mm by the final training session.
• Participants reported high confidence levels in using the headgear.
• The headgear proved to be user-friendly, allowing non-experts to deliver stimulation effectively.

Conclusions

• The personalized headgear enables safe and precise delivery of ME-tES.
• It expands access to neuromodulation treatments for individuals with cognitive deficits.
• The training process enhances the confidence and skills of study partners.

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