全文：
Overview
The CODA 8-Channel High Throughput Non-Invasive Blood Pressure system allows for simultaneous blood pressure measurements in up to eight rodents. Utilizing a tail-cuff method with Volume Pressure Recording (VPR), it accurately assesses blood pressure by monitoring changes in tail blood volume.
Key Study Components
Area of Science
- Cardiovascular research
- Rodent physiology
- Non-invasive measurement techniques
Background
- The CODA system is designed for measuring blood pressure in small animals.
- It employs a non-invasive tail-cuff method to ensure animal welfare.
- Volume Pressure Recording technology enhances measurement accuracy.
- Stable environmental conditions are crucial for reliable results.
Purpose of Study
- To demonstrate the procedure for measuring blood pressure in rodents.
- To provide a detailed setup and operational guide for the CODA system.
- To facilitate cardiovascular research through accurate blood pressure monitoring.
Methods Used
- Setup of the CODA system in a controlled environment.
- Preparation of animals and acclimatization to holders.
- Application of occlusion and VPR cuffs for blood pressure measurement.
- Data collection and analysis of systolic and diastolic blood pressure.
Main Results
- Successful measurement of blood pressure in multiple rodents simultaneously.
- Accurate determination of systolic and diastolic pressures using VPR technology.
- Establishment of protocols for animal handling and data recording.
Conclusions
- The CODA system is effective for non-invasive blood pressure measurement in rodents.
- Proper setup and animal preparation are essential for accurate results.
- This method supports various cardiovascular research applications.
What is the CODA system used for?
The CODA system is used for non-invasive blood pressure measurement in rodents.
How many animals can be measured simultaneously?
The system can measure blood pressure in up to eight animals at once.
What technology does the CODA system utilize?
It uses Volume Pressure Recording (VPR) technology to assess blood pressure.
What is the importance of acclimatizing the animals?
Acclimatization reduces stress and improves the accuracy of blood pressure measurements.
How is systolic blood pressure determined?
Systolic pressure is identified by the first appearance of tail swelling during measurement.
What precautions should be taken during setup?
Ensure a stable temperature and minimize noise and odors to avoid stressing the animals.
繁體中文
