Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis

作者： Xiaoqin Hua1,2, Tobias Deuse1,2, Evangelos D. Michelakis3, Alois Haromy3, Phil S. Tsao4, Lars Maegdefessel4, Reinhold G. Erben5, Claudia Bergow5, Boris B. Behnisch6, Hermann Reichenspurner1,2, Robert C. Robbins7, Sonja Schrepfer1,2,7 1University Heart Center Hamburg,TSI-Lab, Germany, 2Cardiovascular Research Center,University of Hamburg, 3Department of Medicine, Cardiology Division, Pulmonary Hypertension Program,University of Alberta, 4Department of Medicine,Stanford University School of Medicine , 5Department of Biomedical Sciences, Institute of Physiology, Pathophysiology, and Biophysics,University of Veterinary Medicine, Vienna, 6Translumina GmbH,Hechingen, 7Department of Cardiothoracic Surgery,Stanford University School of Medicine

简介：

This video shows a model to study the development of intimal hyperplasia after stent deployment using a human vessel (IMA) in an immunodeficient rat model.

The overall goal of this procedure is to study the development of intimal hyperplasia in a humanized model. This is accomplished by first denuding, a section of human mammary artery or IMA, using a two French fogerty catheter. Next, a stent is inserted into the IMA.

Then a segment of rat abdominal aorta is replaced with a stented IMA. Finally, the wound is sutured and the animal is allowed to recover the endothelial damage due to the invasive procedure of balloon dilatation and stenting results in inflammation and the production of inflammatory cytokines. This leads to the proliferation of smooth muscle cells, which progressively occlude the vessel lumen resulting in stenosis.

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标签: Human Internal Mammary Artery (IMA), Transplantation, Stenting, In-stent Restenosis, Preclinical In Vivo Research Models, Intimal Hyperplasia, Vessel Stenting, Animal Models, Mice, Rats, Rabbits, Pigs, Clinical Settings, Human Research Models, Translational Gap, Reproducible Procedure, Easy Procedure, Fast Procedure, Diverse Stents, Human Vessels, Immunodeficient Rats, Origin Of Proliferating Cells,