Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

作者： Nicolette Driscoll1,2,3, Kathleen Maleski4,5, Andrew G. Richardson2,6, Brendan Murphy1,2,3, Babak Anasori4,5, Timothy H. Lucas2,6, Yury Gogotsi4,5, Flavia Vitale1,2,3,7,8 1Department of Bioengineering,University of Pennsylvania, 2Center for Neuroengineering and Therapeutics,University of Pennsylvania, 3Corporal Michael J. Crescenz Veterans Affairs Medical Center, 4Department of Materials Science and Engineering,Drexel University, 5A.J. Drexel Nanomaterials Institute,Drexel University, 6Department of Neurosurgery,University of Pennsylvania, 7Department of Neurology,University of Pennsylvania, 8Department of Physical Medicine and Rehabilitation

简介：

Overview

This article describes a method for fabricating Ti₃C₂ MXene microelectrode arrays and their application in in vivo neural recording. The technique allows for precise micro-patterning of MXene films while maintaining their integrity.

Key Study Components

Area of Science

• Neuroscience
• Materials Science
• Electrophysiology

Background

• MXenes are a class of two-dimensional materials with promising electrical properties.
• Ti₃C₂ MXene exhibits high metallic conductivity.
• Microelectrode arrays are essential for advanced neural recording techniques.
• Precise fabrication methods are crucial for the performance of neural interfaces.

Purpose of Study

• To develop a reliable method for creating Ti₃C₂ MXene microelectrode arrays.
• To demonstrate the application of these arrays in in vivo neural recording.
• To enhance the understanding of MXene properties in neural applications.

Methods Used

• Preparation of titanium carbide ink through selective etching.
• Micro-patterning of MXene films without damaging the electrodes.
• Centrifugation and washing to achieve desired pH levels.
• Intercalation of lithium chloride to modify MXene properties.

Main Results

• The synthesized MXene ink demonstrated metallic conductivity above 10,000 Siemens per centimeter.
• The microelectrode arrays maintained structural integrity during fabrication.
• Successful application in in vivo neural recording was achieved.
• The method allows for reproducible and scalable production of MXene electrodes.

Conclusions

• This method provides a viable approach for fabricating MXene microelectrode arrays.
• MXene films can be effectively used for advanced neural recording applications.
• The technique opens new avenues for research in neural interfaces.

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